This agent exhibits analgesic, antipyretic, and anticoagulant properties. Acetylsalicylic acid definition of acetylsalicylic acid. The active ingredient acetylsalicylic acid offered by sigmaaldrich is the same chemical as found in aspirin tablets. Synthesis of acetyl salicylic acid aspirin essay example. Aspirin is an orally administered nonsteroidal antiinflammatory agent. It plays a role in how your page is seen by search engine crawlers, and how it appears in serps. However, chemicals for pharmaceutical use are manufactured, tested, and packaged under the regulation of the fda, but chemicals sold for research use do not have the same regulatory oversight. Acetylsalicylic acid definition of acetylsalicylic acid by. Salicylic acid 1 and its derivatives possess antiinflammatory activity due to their inhibition of cyclooxygenases and of nf. A balanced equation for the synthesis of aspirin from salicylic acid and acetic anhydride is the following. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters 150 feet for liquids and at least 25 meters 75 feet for solids.
Aspirin and salicylic acid are stable compounds and are poorly water soluble at acidic and neutral ph. It works by interfering with the production of compounds in the body that cause pain, fever, inflammation, and blood clots. Experiments with aspirin journal of chemical education. Jeffreys follows the story from ancient egypt, where willow was used as a medicine, through to 18th century england, when the reverend edward stone attempted to use willow bark for the treatment of malaria. The drug aspirins trivial chemical name is acetylsalicylic acid, while the systematic one is 2acetoxybenzoic acid. The state of illinois has declared a mandatory shutdown which is currently in place. Nearly 2500 years ago, greeks reported that extracts of willow and poplar bark could be used to relieve pain and symptoms of illness. Find chemical and physical properties, biological activities, safety and toxicity information, patents, literature citations and more.
Using the chemical formulas from figure 1, calculate the molar mass of salicylic acid, acetic. You work for a chemical company and have been task. Read download acetylsalicylic acid pdf pdf download. Acetylsalicylic acid by pharmetics inc acetylsalicylic acid asa belongs to the group of medications called analgesics pain relievers, antipyretics fever reducers, antiinflammatories inflammation reducers, and platelet aggregation inhibitors anticlotting agents. Acetylsalicylic acid, or aspirin, which is derived from salicylic acid, is the most widely used mild analgesic. This structure is also available as a 2d mol file or as a computed 3d sd file. Nmr spectrum of aspirin thermo fisher scientific us. Aspirin is scientifically known as acetylsalicylic acid and, it has a chemical formula of c9h8o4. From folk remedy to pure chemical aspirin is the generic medical name for the chemical acetylsalicylic acid, a derivative of salicylic acid. This actually has an interesting history if you ask me.
Aspirin c 9 h 8 o 4, acetylsalicylic acid, is a salicylate drug used to treat a variety of conditions, including headaches, fever and inflammation. Aspirin, one of the first drugs to come into common usage, is still mostly the widely used in the world approximately 35,000 metric tonnes are produced and consumed annually, enough to make over 100 billion standard aspirin tablets every year. A series of experiments based on aspirin have been used in our high school chemistry laboratory. Acetylsalicylic acid aspirin is a synthetic derivative of salicylic acid that in addition has pronounced antiplatelet properties due to the presence of the acetyl group 43. Structure, properties, spectra, suppliers and links for. Apr 27, 2019 along with its needed effects, aspirin the active ingredient contained in acetylsalicylic acid may cause some unwanted effects. It is also used in low doses in preventive treatment against heart attacks, strokes and blood clots. Aspirin, the most widely used drug in the world, has an interesting history. The present experiment will be the synthesis of a familiar organic compound called aspirin. Aspirin definition nci an orally administered nonsteroidal antiinflammatory agent. One of the compounds used in the synthesis of aspirin is salicylic acid, which is itself a pain reliever that was known to many ancient cultures, including the native americans who extracted it from willow tree bark.
Aspirin should not be given to children who have viral infections, because this has been associated with the subsequent development of reyes syndrome. This second, completely revised edition contains the latest results of clinical and pharmacological research on acetylsalicylic acid, addressing the multiple pharmacological properties of this famous drug with a balanced view on their translation into clinical practice, including prevention from cardiovascular diseases and colorectal cancer. For pain or fever, effects typically begin within 30 minutes. However, it is still an acid, and given that some people consume relatively large amounts of aspirin daily, its acidic nature can cause problems in the stomach lining, despite the stomachs defenses against its own stomach acid. Excerpt from erg guide 154 substances toxic andor corrosive noncombustible. Acetylsalicylic acid side effects, uses, dosage, overdose. There are significant differences between a protein therapeutic and a small molecule drug.
Diagnosis and treatment, vale and meredith eds, update books, london. By understanding the properties of this molecule, it is easier to understand how the. Check with your doctor immediately if any of the following side effects occur while taking aspirin. Acetylsalicylic acid an overview sciencedirect topics. Acetylsalicylic acid, marketed under the trade name aspirin by the bayer company, is one of the most widely consumed. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation. Your chance to have a onetoone lesson with bestselling language expert paul noble, try a free audio sample of. Aspirin is also used longterm to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. Synthesis of aspirin lab report 2989 words bartleby. A meta description is an html tag in the html code of your website, which allows you to customize a section of text that describes the page itself.
This structure is also available as a 2d mol file or as a. Highlighting the historical evolution of the salicylates and the commercial development of. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever. You work for a chemical company and have been tasked with synthesizing acetylsalicylic acid. A reference on chemical compounds explains types of chemical compounds and their molecular and structural formulas and includes entries on one hundred familiar and less wellknown compounds, chosen because of their importance to health, industry. Explore more about uses, structure and method of preparation at.
Acetylsalicylic acid chemicalbookchemical search engine. In the us, acetylsalicylic acid is a member of the following drug classes. See salicylate for adverse reactions and poisoning. Aspirin or acetylsalicylic acid acetosal is a drug in the family of salicylates, often used as an analgesic. Henar martinezgarcia, in experimental organic chemistry, 2016. Acetylsalicylate definition of acetylsalicylate by merriam. The unlimited availability of entirely synthetic salicylic acid as a result of marked progress in organic chemistry in the late nineteenth century and the positive results with the compound in daily practice, including its medical use as an anti. Pubchem is the worlds largest collection of freely accessible chemical information.
Acetylsalycilic acid and drugs that contain it are produced by dozens of manufacturers from different countries. Aspirin, the ubiquitous pain reliever, goes by the chemical name acetylsalicylic acid. It finds use today among others as the active metabolite of acetylsalicylic acid asa, an acne treatment a chemical exfoliant and as a chemical reagent. Using the chemical formulas from figure 1, calcula. Choose from 77 different sets of asprin flashcards on quizlet. Salicylic acid was esterfied using acetic acid and sulfuric acid acting as a catalyst to produce acetylsalicylic acid and acetic acid. Aspirin or acetylsalicylic acid acetosal is a drug in the family of salicylates, often used as an analgesic against minor pains and aches, antipyretic against fever, and antiinflammatory. To synthesize aspirin from salicylic acid and acetic anhydride. Synthesis of aspirin experiment chemistry libretexts.
Aspirin, also known as acetylsalicylic acid, is a medication used to reduce pain, fever, or inflammation. Although not all of these side effects may occur, if they do occur they may need medical attention. Buffers introductory chemistry 1st canadian edition. Compounds of salicylic acid are found in some plants, notably white willow and meadowsweet spirea ulmaria. Acetylsalicylic acid asa irreversibly inhibits cyclooxygenase1 and results in blocking the formation and release of thromboxane a2, a potent platelet activator. Aspirin acetylsalicylic acid is prepared by heating. Acetylsalicylate definition is a salt or ester of acetylsalicylic acid. From experience to design the science behind aspirin. Salicylic acid exist as clear white or colourless and odourless needleshaped crystals at room temperature. Salicylic acid uses, structure, properties and method of. In a business making drugs based on, for example, acetylsalicylic acid, a product that has been on the market for well over 100 years, the chances are there is often no new knowledge to be gained from psurs periodic safety update reports and single case handling, yet the dogged reporting and analysis still has to take place in order to. Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antiinflammatory compound that inhibits cox1target. Jun 10, 2016 this second, completely revised edition contains the latest results of clinical and pharmacological research on acetylsalicylic acid, addressing the multiple pharmacological properties of this famous drug with a balanced view on their translation into clinical practice, including prevention from cardiovascular diseases and colorectal cancer. Visit chemicalbook to find more acetylsalicylic acid50782 information like chemical properties,structure,melting point,boiling point,density,molecular formula.
Acetylsalicylic acid chemical properties,uses,production whats acetylsalicylic acid. Read online acetylsalicylic acid and download acetylsalicylic acid book full in pdf formats. Flinn lab chemicals, your safer source for science. It is a white crystalline powder, odorless, stable in dry air. Pdf preparing a pure aspirin acetylsalicylic acid researchgate. The phenol group that will attack the carbonyl carbon of the acetic anhydride is the oh group that is directly attached to the benzene since it is more basic than the oh group attached to the carbonyl group. It is obvious that size and complexity are orders of magnitude different between the molecules. The first known use of acetylsalicylate was in 1893. Acetylsalicylic acid,50782,price,manufacturer,supplier. However, chemicals for pharmaceutical use are manufactured, tested, and packaged under the regulation of the fda, but chemicals sold for research use.
H 2 so 4 use a dropper, h 2 so 4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves. As an essential business serving the needs of the education and healthcare communities, we will be continuing to process and ship orders as well as provide ongoing customer service support. Introduction most drugs are chemical compounds which are described as organic compounds because they are comprised primarily of the elements carbon, hydrogen and oxygen. Following promising pilot studies with highdose aspirin 2, salsalate 3, a prodrug of salicylic acid, produced a highly significant reduction in blood glucose, hemoglobina1c. This colorless crystalline organic acid is widely used in organic synthesis and functions as a plant hormone. Salicylic acid from latin salix, willow tree is a lipophilic monohydroxybenzoic acid, a type of phenolic acid, and a beta hydroxy acid bha.
It is considered the prototype aspirin is sometimes used in the prevention of certain diseases, though its role as a preventive agent is controversial because of the risk of adverse effects. Specifies the medication aspirin acetylsalicylic acid, aspirin, arthritis foundation safety coated aspirin, bayer aspirin, bayer childrens aspirin, ecotrin, and many others, a drug used for the treatment of arthritis, pain, inflammation, and fever. The chapter discusses the chemical structures and physicochemical properties of aspirin and other. One of the most brilliant medical historians and journalists of our time, the late roy porter, wrote a book called the greatest benefit to. Therefore we are able to calculate the number of moles of salicylic acid using the equation. Using the chemical formulas from figure 1, calculate the molar mass of salicylic acid, acetic anhydride and acetylsalicylic acid aspirin.
Aspirin, also known as acetylsalicylic acid asa, is a medication used to treat pain, fever, or inflammation. Aspirin, also called acetylsalicylic acid, derivative of salicylic acid that is a mild nonnarcotic analgesic pain reliever useful in the relief of headache and muscle and joint aches. By understanding the properties of this molecule, it is easier to understand how the molecule acts and works as a drug. Reviewing over a century of aspirin research and use, aspirin and related drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin. Cox1aspirin usan, also known as acetylsalicylic acid, is a salicylate drug, often used as ananalgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti. Experiments include i synthesis, purification, and characterization of aspirin by mp and tlc, ii percentage composition of a commercial aspirin tablet by titration, iii kinetics of the hydrolysis of aspirin to salicylic acid under various conditions, iv synthesis and characterization of.
Acetylsalicylic acid aspirin, asp, a frequently used analgesic and antipyretic drug, has prevailed for decades due to its multiple functions. Acetylsalicylic acid price,buy acetylsalicylic acid chemicalbook. Aspirin hc9h7o4 or c9h8o4 cid 2244 structure, chemical names, physical and chemical properties. However, it still caused gastric discomfort problems. Asa is effective in the entire clinical spectrum of cad and with different therapeutic strategies. Salicylic acid is a small aromatic acid whose chemical name is monohydroxybenzoic acid. In some countries, this medicine may only be approved for veterinary use. Acetylsalicylic acid is the chemical name for aspirin. The acid was given the name aspirin, from the a for acetyl and the spirin from spirea, the genus name for shrubs that are an alternative source of salicylic acid, writes the chemical. Aspirin acetylsalicylic acid is prepared by heating salicylic acid, c 7 h 6 o 3, with acetic anhydride, c 4 h 6 o 3.
It may also decrease the risk of certain types of cancer, particular. Wear appropriate protective eyeglasses or chemical safety goggles as described by oshas eye and face protection regulations in 29 cfr 1910. Aspirin given shortly after a heart attack decreases the risk of death. Acetylsalicylic acid definition and meaning collins. Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. Preparation and characterization of acetylsalicylic acid. Search chemicals by name, molecular formula, structure, and other identifiers.
Aspirin, also known as acetylsalicylic acid, has a chemical formula of c9h8o4. In 1853 the french chemist charles gerhardt synthesised acetylsalicylic acidthe active ingredient of willow bark. Ethanol dissolved acetylsalicylic acid was successfully loaded with chitosangelatin via epd and showed outstanding osteogenesis and mechanical properties. Aspirin is effective in reducing fever, inflammation, and swelling and thus has been used for treatment of rheumatoid arthritis, rheumatic fever, and mild. Aspirin poisons the platelets for its remaining life using an example patient with 250,000 platelet count new platelets are generated at a rate of 10% per day 25,000day for a patient with a 250,000 platelet count by 2 days off aspirin, a patient will have 50,000 normal platelets enough to counter bleeding. Acetylsalicylic acid, also known as aspirin, is an analgesicantipyretic medicine made by salicylic acid interacting with acetic anhydride. Jul 27, 2017 acetylsalicylic acid get uptodate information on acetylsalicylic acid side effects, uses, dosage, overdose, pregnancy, alcohol and more. Finally, the purity of the purified dry aspirin crystals can be determined by. Acetylsalicylic acid was purchased from sinopharm chemical reagent co. Chemicalbook provideacetylsalicylic acid 50782 1h nmr,ir2,ms,ir3,ir1,1h nmr,raman,esr,c nmr,spectrum. Explore more about uses, structure and method of preparation at vedantu.
General aspects acetylsalicylic acid wiley online library. Salicylic acid s formula is c 6 h 4 ohcooh and its iupac name is 2hydroxybenzoic acid. Dec 11, 2004 jeffreys follows the story from ancient egypt, where willow was used as a medicine, through to 18th century england, when the reverend edward stone attempted to use willow bark for the treatment of malaria. Aspirin is only found in individuals who have consumed this drug.